Epigenetic Modifications of Immune Cells and their Importance for Alloimmunity

Date: September 12, 2018

Time: 02:00PM - 03:00PM

You must be registered to participate!

After participating in this webinar, the learner will be able to:

  • Describe an overview of genomic and epigenomic topics that are relevant to alloimmunity.
  • Define epigenetics, outline basic concepts and processes.
  • Outline examples of DNA methylation controlling T cell function.
  • Outline examples of histone modifications controlling T cell function.
  • Describe examples of epigenetic factors contributing to organ transplant rejection in rodent models.
  • Describe a clinical example of epigenetic drug targeting in allogenic bone marrow transplantation to alleviate GVHD.
  • Outline basic concepts in genomics and epigenomics.
  • Describe 3-dimensional regulatory architectures of inflammatory genes in T cells.
  • Discuss the use of 3D epigenomics to understand the basis of genetic susceptibility to inflammatory disease in humans.