After participating in this webinar, the learner will be able to:

• Describe an overview of genomic and epigenomic topics that are relevant to alloimmunity.
• Define epigenetics, outline basic concepts and processes.
• Outline examples of DNA methylation controlling T cell function.
• Outline examples of histone modifications controlling T cell function.
• Describe examples of epigenetic factors contributing to organ transplant rejection in rodent models.
• Describe a clinical example of epigenetic drug targeting in allogenic bone marrow transplantation to alleviate GVHD.
• Outline basic concepts in genomics and epigenomics.
• Describe 3-dimensional regulatory architectures of inflammatory genes in T cells.
• Discuss the use of 3D epigenomics to understand the basis of genetic susceptibility to inflammatory disease in humans.