Our approach to organ preservation has been based on cold storage in buffer solutions, which can augment ischemia reperfusion injury. It may be time to change our views based on new basic and clinical research data. However, is this acceptable for all organs and can the lessons from liver be generalized? Dr. Friend will discuss the development of his exciting OrganOx system from animal models to first-in-human clinical trials currently being conducted at King’s College Hospital in London.