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AST 2014 - Cutting Edge of Transplantation


FR01d - Disrupting Old Concepts of Cell Death: Implications for Modifying Organ Preservation at the Molecular Level


Feb 14, 2014 8:45am ‐ Feb 14, 2014 9:15am

Description

Traditional views of cell death include programmed apoptosis and uncontrolled necrosis. It appears now that both are programmed and have emerging therapeutics, and that caspase-8 – which is involved in apoptosis – may function primarily to control necrosis. The implications for transplantation are tremendous, as organ injury is invariably caused by the procurement and storage procedure, and intervention without understanding the complex biology will have unintended complications.

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