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CTC Files


Topic #2 (Pharm)


Oct 8, 2019 3:00pm ‐ Oct 8, 2019 3:00pm

Description

"Maintenance Immunosuppression"

This lecture covers "part 2" of Immunosuppression pharmacokinetics & therapeutic drug monitoring ("Maintenance Immunosuppression").

The objectives of this lecture are to understand the basic pharmacokinetic characteristics impacting drug dosing using:

  1. Calcineurin inhibitors (CNI)
  2. Mammalian target of rapamycin (mTOR)
  3. Antiproliferative agents
  4. Corticosteroids, and
  5. Costimulatory Blockers

Use the markers on the video timeline to quickly navigate to important points in the video outlined below:
- Chapter 1: Objectives [1:04]
- Chapter 2: Introduction to Pharmacokinetic Principles [1:32]
- Chapter 3: Calcineurin Inhibitors [5:50]
           - Section A) CNI Pharmacokinetic Parameters [5:57]
           - Section B) CNI Metabolism [8:40]
           - Section C) CNI Dosing and Monitoring [10:56]
           - Section D) Cyclosporine [14:05]
           - Section E) Tacrolimus [16:14]
- Chapter 4: Mammalian Target of Rapamycin (mTOR) Inhibitors [27:01]
           - Section A) mTOR Pharmacokinetic Parameters [27:12]
           - Section B) mTOR Dosing and Monitoring [28:24]
- Chapter 5: Antiproliferative Agents [30:15]
           - Section A) mTOR Mycophenolate [30:32]
           - Section B) Azathioprine [35:58]
- Chapter 6: Corticosteroids [37:55]
- Chapter 7: Belatacept [39:23]
- Chapter 8: Conclusion [42:09]

 

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