B cells and plasma cells mediate functions critical to transplant success, including antibody production and antigen presentation, as well as positive and negative immunoregulatory activities. Understanding how the size and composition of pre-immune and antigen-experienced B cell niches are regulated should enable targeted prophylactic and therapeutic interventions. This presentation will overview current thought about the establishment and regulation of these different niches, highlighting emerging ideas relevant to their clinical manipulation.
What You'll Take Away from His Talk:
Pre-immune and antigen experienced B cell subsets occupy independent homeostatic niches.
Selection and survival in each niche is mediated by different key molecular families and signaling systems. These include the B cell antigen receptor complex, BLyS (BAFF) family members, and other positive and negative regulators.
Targeting appropriate members of these molecular families may allow the selective manipulation of B cell subsets to clinical advantage.