The major question that I will address in my talk is how B cells regulate CD4 and CD8 T cell responses. We will show that B cells regulate T cell responses by both antibody dependent and independent mechanisms and therefore are important modulators of cellular immunity in the context of infection, autoimmunity and transplantation.
What You'll Take Away from Her Talk:
B cells regulate primary and memory CD4 and CD8 T cell responses via antibody independent mechanisms.
Antibody and antibody immune complexes can regulate DC-mediated development of CD8 memory responses to some, but not all, antigens.