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AST 2013 - Cutting Edge of Transplantation


FR08 - The Role of Complement in Organ Injury and Immune Regulation


Feb 15, 2013 12:00pm ‐ Feb 15, 2013 12:30pm

Description

Perched at the interface of transplants and environment threats of all types and the host, complement serves three distinct functions: (i) it recognizes for surfaces; (ii) it injures or directs immune attack against those surfaces; and (iii) it orchestrates immunity, inflammation, resistance to injury (accommodation) and healing. This lecture will consider how complement fulfills these roles and how, in particular, complement might support, and not just undermine, the well being of a graft.

What You'll Take Away from His Talk:

  • How the complement system is recruited in transplants, potentially allowing more direct and specific detection and control.
  • Benefits complement confers on grafts.
  • How complement regulates immunity to the graft and to infectious agents.

Speaker(s):

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