In the past few years, the concepts of calculated PRA (cPRA) and virtual crossmatching (vXM) have been embraced by the transplant community. As a result, organ allocation is more efficient and a greater proportion of highly sensitized patients are being transplanted. Has the time arrived when physical crossmatches no longer need to be performed? HLA antibodies come in all types of varieties. Different isotypes, different complement fixing ability, different affinities for their complementary antigens, different titers. How , then, can a single “cutoff” value of antibody level (below which is negative and above which is positive) be expected to correspond with its clinical relevance?
What You'll Take Away from His Talk:
Distinguish HLA antibodies from non-HLA antibodies.
Understand the difference between PRA and calculated PRA (cPRA).
Recognize the clinical relevance of “complete” HLA donor typing.