I will be discussing current methods for desensitization as well as ongoing clinical trials we are conducting. Currently, there are several unresolved controversies and questions regarding the efficacy and economics of desensitization. I will address these and hopefully help clarify some of the outstanding controversies. I would hope that the audience would come away with a better understanding of the options and opportunities for transplantation that are created by desensitization. Also, what the future holds and how to refine desensitization protocols to insure the appropriate patients are treated and parameters for choosing an appropriate kidney for each patient are clearly defined.