After participating in this webinar, the learner will be able to:

Describe an overview of genomic and epigenomic topics that are relevant to alloimmunity.
Define epigenetics, outline basic concepts and processes.
Outline examples of DNA methylation controlling T cell function.
Outline examples of histone modifications controlling T cell function.
Describe examples of epigenetic factors contributing to organ transplant rejection in rodent models.
Describe a clinical example of epigenetic drug targeting in allogenic bone marrow transplantation to alleviate GVHD.
Outline basic concepts in genomics and epigenomics.
Describe 3-dimensional regulatory architectures of inflammatory genes in T cells.
Discuss the use of 3D epigenomics to understand the basis of genetic susceptibility to inflammatory disease in humans.

Andrew Wells PhD

University of Pennsylvania and CHOP